Product Data Sheet
JAK2-IN-15
Catalog No. A33349
JAK2-IN-15 is a potent and selective inhibitor of JAK2, exhibiting an IC50 value of 1.17 nM. It effectively targets the JAK2-STAT signaling pathway, making it a valuable tool for investigating therapeutic strategies. In preclinical studies, JAK2-IN-15 has demonstrated significant improvements in hematocrit levels and reductions in splenomegaly in an Epoetin beta-induced mouse model. This compound is particularly relevant for research into Polycythemia Vera (PV) and related hematological disorders.
Chemical Information
| Catalog Num | A33349 |
|---|---|
| M. Wt | 517.62 |
| Formula | C29H35N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3094174-82-7 |
| Synonyms | |
| SMILES | CC1=C2N=C(NC3=CC=C(C(COC/C=C/COCC4=CC=CC(N2)=C4)=C3)OCCN5CCOCC5)N=C1 |
Biological Activity
| Description | JAK2-IN-15 is a potent and selective inhibitor of JAK2, exhibiting an IC50 value of 1.17 nM. It effectively targets the JAK2-STAT signaling pathway, making it a valuable tool for investigating therapeutic strategies. In preclinical studies, JAK2-IN-15 has demonstrated significant improvements in hematocrit levels and reductions in splenomegaly in an Epoetin beta-induced mouse model. This compound is particularly relevant for research into Polycythemia Vera (PV) and related hematological disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
