Product Data Sheet
JAK1/TYK2-IN-5
Catalog No. A33384
JAK1/TYK2-IN-5 is a potent inhibitor of JAK1 and TYK2, exhibiting Ki values of 0.0044 nM for TYK2 JH2 and 0.02 nM for JAK1 JH2, demonstrating high specificity and potency. This compound effectively inhibits interferon-alpha (IFNα) induced activation of the STAT signaling pathway mediated by TYK2 and JAK1. JAK1/TYK2-IN-5 is useful in research applications focused on cytokine signaling, immune response modulation, and the development of therapies targeting autoimmune diseases and inflammatory conditions.
Chemical Information
| Catalog Num | A33384 |
|---|---|
| M. Wt | 535.53 |
| Formula | C26H30N7O4P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3026367-07-4 |
| Synonyms | |
| SMILES | O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C(P(C5CC5)(C6CC6)=O)=C4)=C3OC)N |
Biological Activity
| Description | JAK1/TYK2-IN-5 is a potent inhibitor of JAK1 and TYK2, exhibiting Ki values of 0.0044 nM for TYK2 JH2 and 0.02 nM for JAK1 JH2, demonstrating high specificity and potency. This compound effectively inhibits interferon-alpha (IFNα) induced activation of the STAT signaling pathway mediated by TYK2 and JAK1. JAK1/TYK2-IN-5 is useful in research applications focused on cytokine signaling, immune response modulation, and the development of therapies targeting autoimmune diseases and inflammatory conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
