Product Data Sheet
JAK1-IN-18
Catalog No. A33386
JAK1-IN-18 is a selective inhibitor of Janus kinase 1 (JAK1), exhibiting an IC50 of 0.15 nM for JAK1 while demonstrating significantly reduced activity against JAK2 and JAK3. This compound has been shown to effectively diminish inflammation in preclinical models of ulcerative colitis and Crohn's disease. It is suitable for research applications targeting autoimmune diseases, viral infections, and hematological malignancies, making it a valuable tool in the study of these conditions.
Chemical Information
| Catalog Num | A33386 |
|---|---|
| M. Wt | 366.37 |
| Formula | C16H20F2N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2459377-98-9 |
| Synonyms | |
| SMILES | O=C(NCC(F)F)[C@@H]1CN(CCC1)NC2=C3C(NC=C3)=NC=C2C(N)=O |
Biological Activity
| Description | JAK1-IN-18 is a selective inhibitor of Janus kinase 1 (JAK1), exhibiting an IC50 of 0.15 nM for JAK1 while demonstrating significantly reduced activity against JAK2 and JAK3. This compound has been shown to effectively diminish inflammation in preclinical models of ulcerative colitis and Crohn's disease. It is suitable for research applications targeting autoimmune diseases, viral infections, and hematological malignancies, making it a valuable tool in the study of these conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
