Product Data Sheet
Tyk2-IN-23
Catalog No. A33392
Tyk2-IN-23 is a selective TYK2 inhibitor with an IC50 of 18 nM, demonstrating over 70-fold selectivity against JAK isoforms 1, 2, and 3. This compound effectively inhibits phosphorylated STAT3 in TYK2-dependent signaling pathways activated by interferon-alpha (IFN-α) and interleukin-10 (IL-10). Additionally, Tyk2-IN-23 significantly reduces IFN-α-induced STAT1 phosphorylation in H9 cells, making it a valuable tool for the investigation of alopecia areata and allergic rhinitis.
Chemical Information
| Catalog Num | A33392 |
|---|---|
| M. Wt | 495.98 |
| Formula | C26H27ClFN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2734918-75-1 |
| Synonyms | |
| SMILES | O=C1NCCC21CCN(C3=C(C)C=NC(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)=N3)CC2 |
Biological Activity
| Description | Tyk2-IN-23 is a selective TYK2 inhibitor with an IC50 of 18 nM, demonstrating over 70-fold selectivity against JAK isoforms 1, 2, and 3. This compound effectively inhibits phosphorylated STAT3 in TYK2-dependent signaling pathways activated by interferon-alpha (IFN-α) and interleukin-10 (IL-10). Additionally, Tyk2-IN-23 significantly reduces IFN-α-induced STAT1 phosphorylation in H9 cells, making it a valuable tool for the investigation of alopecia areata and allergic rhinitis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
