Product Data Sheet
Tyk2-IN-22
Catalog No. A33410
Tyk2-IN-22 is a selective inhibitor of tyrosine kinase 2 (Tyk2) with a notable inhibition profile, exhibiting IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM against Tyk2, JAK1, and JAK3, respectively. This compound effectively inhibits downstream phosphorylation of STAT5, making it a valuable tool for studying Tyk2-mediated signaling pathways. Tyk2-IN-22 is suitable for research applications related to autoimmune diseases, inflammatory conditions, and cancer therapies targeting JAK-STAT signaling.
Chemical Information
| Catalog Num | A33410 |
|---|---|
| M. Wt | 345.78 |
| Formula | C16H16ClN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 933667-23-3 |
| Synonyms | |
| SMILES | O=C1N2C(NC(C3=CC=C(Cl)C=C3)=N2)=NC(CN4CCOCC4)=C1 |
Biological Activity
| Description | Tyk2-IN-22 is a selective inhibitor of tyrosine kinase 2 (Tyk2) with a notable inhibition profile, exhibiting IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM against Tyk2, JAK1, and JAK3, respectively. This compound effectively inhibits downstream phosphorylation of STAT5, making it a valuable tool for studying Tyk2-mediated signaling pathways. Tyk2-IN-22 is suitable for research applications related to autoimmune diseases, inflammatory conditions, and cancer therapies targeting JAK-STAT signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
