Product Data Sheet
JAK1-IN-17
Catalog No. A33432
JAK1-IN-17 is a highly selective inhibitor of Janus kinase 1 (JAK1), exhibiting a Ki of 1.9 nM. This compound maintains effective potency in whole blood due to its low whole blood shift, making it a valuable tool for hematological studies. Additionally, JAK1-IN-17 is a nitrile-containing analogue that displays weak reversible inhibition of CYP3A4, demonstrated by an IC50 of 7.9 μM. Researchers can utilize JAK1-IN-17 in cancer research to explore the therapeutic potential of JAK1 inhibition in various malignancies.
Chemical Information
| Catalog Num | A33432 |
|---|---|
| M. Wt | 309.37 |
| Formula | C17H19N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1315490-71-1 |
| Synonyms | |
| SMILES | N#C[C@H]1CC[C@H](N2C([C@H](O)C)=NC3=CN=C(NC=C4)C4=C32)CC1 |
Biological Activity
| Description | JAK1-IN-17 is a highly selective inhibitor of Janus kinase 1 (JAK1), exhibiting a Ki of 1.9 nM. This compound maintains effective potency in whole blood due to its low whole blood shift, making it a valuable tool for hematological studies. Additionally, JAK1-IN-17 is a nitrile-containing analogue that displays weak reversible inhibition of CYP3A4, demonstrated by an IC50 of 7.9 μM. Researchers can utilize JAK1-IN-17 in cancer research to explore the therapeutic potential of JAK1 inhibition in various malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
