Product Data Sheet
JAK1-IN-19
Catalog No. A33435
JAK1-IN-19 is a potent inhibitor of Janus kinase 1 (JAK1), demonstrating IC50 values of 0.02 nM for JAK1, 0.5 nM for JAK2, 91 nM for JAK3, and 0.2 nM for TYK2. This compound exhibits enhanced intrinsic clearance in both rat and human models. JAK1-IN-19 is applicable for research in atopic dermatitis and other autoimmune diseases, facilitating the investigation of JAK1 signaling pathways and their role in inflammatory responses.
Chemical Information
| Catalog Num | A33435 |
|---|---|
| M. Wt | 391.43 |
| Formula | C20H21N7O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2169271-17-2 |
| Synonyms | |
| SMILES | N#C[C@@H]1[C@H](COCC1)N2N=C(C(C(N)=O)=C2)NC3=CC=C(C4=CN(N=C4)C)C=C3 |
Biological Activity
| Description | JAK1-IN-19 is a potent inhibitor of Janus kinase 1 (JAK1), demonstrating IC50 values of 0.02 nM for JAK1, 0.5 nM for JAK2, 91 nM for JAK3, and 0.2 nM for TYK2. This compound exhibits enhanced intrinsic clearance in both rat and human models. JAK1-IN-19 is applicable for research in atopic dermatitis and other autoimmune diseases, facilitating the investigation of JAK1 signaling pathways and their role in inflammatory responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
