Product Data Sheet
INCB16562
Catalog No. A33438
INCB16562 is a selective inhibitor targeting JAK1 and JAK2, with a notable preference for JAK1 over JAK3. It effectively inhibits interleukin-6 (IL-6)-induced phosphorylation of STAT3, thereby blocking the proliferation and survival of myeloma cells reliant on IL-6 for growth. Furthermore, INCB16562 demonstrates antitumor activity in vivo by reducing the growth of myeloma xenografts in murine models. This compound shows potential for advancing research in multiple myeloma therapies.
Chemical Information
| Catalog Num | A33438 |
|---|---|
| M. Wt | 380.23 |
| Formula | C19H11Cl2N5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 933768-63-9 |
| Synonyms | |
| SMILES | ClC1=CC=CC(Cl)=C1C2=NC3=C(N2)C4=C(C=NC=C4)NC5=C3C=CC=N5 |
Biological Activity
| Description | INCB16562 is a selective inhibitor targeting JAK1 and JAK2, with a notable preference for JAK1 over JAK3. It effectively inhibits interleukin-6 (IL-6)-induced phosphorylation of STAT3, thereby blocking the proliferation and survival of myeloma cells reliant on IL-6 for growth. Furthermore, INCB16562 demonstrates antitumor activity in vivo by reducing the growth of myeloma xenografts in murine models. This compound shows potential for advancing research in multiple myeloma therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
