Product Data Sheet
JAK1/2-IN-2
Catalog No. A33440
JAK1/2-IN-2 is a highly selective inhibitor of the Janus kinase 1 and 2 (JAK1/2) pathways, demonstrating Ki values of 2 nM and 0.6 nM, respectively. This compound is instrumental in research focused on the modulation of cytokine signaling pathways and holds potential for therapeutic applications in autoimmune diseases and hematological malignancies. Its potent inhibition of JAK1/2 makes it a valuable tool for understanding the role of these kinases in various biological processes.
Chemical Information
| Catalog Num | A33440 |
|---|---|
| M. Wt | 321.34 |
| Formula | C16H15N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1470249-04-7 |
| Synonyms | |
| SMILES | O=C1C2=NC(C3=CNN=C3)=NC(N[C@@H]4[C@@H](CCC4)C#N)=C2C=CN1 |
Biological Activity
| Description | JAK1/2-IN-2 is a highly selective inhibitor of the Janus kinase 1 and 2 (JAK1/2) pathways, demonstrating Ki values of 2 nM and 0.6 nM, respectively. This compound is instrumental in research focused on the modulation of cytokine signaling pathways and holds potential for therapeutic applications in autoimmune diseases and hematological malignancies. Its potent inhibition of JAK1/2 makes it a valuable tool for understanding the role of these kinases in various biological processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
