Product Data Sheet
Nintedanib-d8
Catalog No. A33483
Nintedanib-d8 is a deuterated form of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. With IC50 values of 34 nM, 13 nM, 69 nM, and 59 nM for these receptors, Nintedanib-d8 serves as a valuable stable isotope for analytical studies. This compound is primarily used in research focusing on angiogenesis and related signaling pathways, assisting in the elucidation of drug metabolism and pharmacokinetics.
Chemical Information
| Catalog Num | A33483 |
|---|---|
| M. Wt | 547.67 |
| Formula | C31H25D8N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1624587-87-6 |
| Synonyms | BIBF 1120-d8 |
| SMILES | CN(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])N1CC(N(C)C(C=C2)=CC=C2N/C(C3=CC=CC=C3)=C4C5=CC=C(C(OC)=O)C=C5NC/4=O)=O |
Biological Activity
| Description | Nintedanib-d8 is a deuterated form of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. With IC50 values of 34 nM, 13 nM, 69 nM, and 59 nM for these receptors, Nintedanib-d8 serves as a valuable stable isotope for analytical studies. This compound is primarily used in research focusing on angiogenesis and related signaling pathways, assisting in the elucidation of drug metabolism and pharmacokinetics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
