Product Data Sheet
Pazopanib-13C,d3 hydrochloride
Catalog No. A33501
Pazopanib-13C,d3 hydrochloride is a stable isotope-labeled form of Pazopanib hydrochloride, featuring deuterium and carbon-13 isotopes. It acts as a multi-target inhibitor, primarily affecting VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This reagent is valuable for biochemical studies and metabolic tracing applications in cancer research and related fields, allowing for detailed investigation of dose-response relationships and pharmacokinetics.
Chemical Information
| Catalog Num | A33501 |
|---|---|
| M. Wt | 477.99 |
| Formula | C2013CH21D3ClN7O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1261398-44-0 |
| Synonyms | GW786034-13C,d3 hydrochloride |
| SMILES | CC1=C2C(C=C(C=C2)N(C3=NC(NC4=CC(S(N)(=O)=O)=C(C=C4)C)=NC=C3)[13C]([2H])([2H])[2H])=NN1C.Cl |
Biological Activity
| Description | Pazopanib-13C,d3 hydrochloride is a stable isotope-labeled form of Pazopanib hydrochloride, featuring deuterium and carbon-13 isotopes. It acts as a multi-target inhibitor, primarily affecting VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This reagent is valuable for biochemical studies and metabolic tracing applications in cancer research and related fields, allowing for detailed investigation of dose-response relationships and pharmacokinetics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
