Product Data Sheet
Nintedanib-d3
Catalog No. A33502
Nintedanib-d3 is a deuterated analogue of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. This compound exhibits IC50 values of 34 nM for VEGFR1, 13 nM for VEGFR2 and 3, 69 nM for FGFR1, 37 nM for FGFR2, 108 nM for FGFR3, and 59 nM and 65 nM for PDGFRα and β, respectively. Nintedanib-d3 is ideal for studies involving metabolic pathways, pharmacokinetics, and isotope labeling in biological research.
Chemical Information
| Catalog Num | A33502 |
|---|---|
| M. Wt | 542.64 |
| Formula | C31H30D3N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1624587-84-3 |
| Synonyms | BIBF 1120-d3 |
| SMILES | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C([2H])([2H])[2H])CC4)=O)C=C3)/C5=CC=CC=C5)OC |
Biological Activity
| Description | Nintedanib-d3 is a deuterated analogue of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. This compound exhibits IC50 values of 34 nM for VEGFR1, 13 nM for VEGFR2 and 3, 69 nM for FGFR1, 37 nM for FGFR2, 108 nM for FGFR3, and 59 nM and 65 nM for PDGFRα and β, respectively. Nintedanib-d3 is ideal for studies involving metabolic pathways, pharmacokinetics, and isotope labeling in biological research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
