Product Data Sheet
Ponatinib-d8
Catalog No. A33507
Ponatinib-d8 is a deuterated form of the multi-targeted kinase inhibitor Ponatinib, designed for use in stable isotope labeling studies. With high potency, Ponatinib selectively inhibits crucial kinases including Abl (IC50 = 0.37 nM), PDGFRα (1.1 nM), VEGFR2 (1.5 nM), FGFR1 (2.2 nM), and Src (5.4 nM). This reagent is particularly valuable in biochemical research aimed at elucidating kinase signaling pathways and evaluating therapeutic responses in cancer research.
Chemical Information
| Catalog Num | A33507 |
|---|---|
| M. Wt | 540.61 |
| Formula | C29H19D8F3N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1562993-37-6 |
| Synonyms | AP24534-d8 |
| SMILES | O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3 |
Biological Activity
| Description | Ponatinib-d8 is a deuterated form of the multi-targeted kinase inhibitor Ponatinib, designed for use in stable isotope labeling studies. With high potency, Ponatinib selectively inhibits crucial kinases including Abl (IC50 = 0.37 nM), PDGFRα (1.1 nM), VEGFR2 (1.5 nM), FGFR1 (2.2 nM), and Src (5.4 nM). This reagent is particularly valuable in biochemical research aimed at elucidating kinase signaling pathways and evaluating therapeutic responses in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
