Product Data Sheet
Si5-N14
Catalog No. A33577
Si5-N14 is a siloxane-based lipid nanoparticle component that enhances vascular repair and exhibits anti-tumor properties. It effectively facilitates CRISPR-Cas9 editing in transgenic GFP mice and demonstrates an ability to knock out Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in Lewis lung carcinoma models, contributing to tumor suppression. Additionally, Si5-N14 has been shown to deliver Fibroblast Growth Factor-2 (FGF-2) mRNA in models of viral-induced lung injury, promoting vascular repair, increasing blood oxygen levels, and enhancing lung function. This reagent holds significant potential for research applications in oncology, pulmonary disease, and cardiovascular health.
Chemical Information
| Catalog Num | A33577 |
|---|---|
| M. Wt | 1318.31 |
| Formula | C78H160N6O5Si2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3006860-57-4 |
| Synonyms | |
| SMILES | O=C(CCN(CCC[Si](C)(C)O[Si](C)(CCCN(CCC(NCCCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCCCC)=O)C)CCC(NCCCCCCCCCCCCCC)=O)NCCCCCCCCCCCCCC |
Biological Activity
| Description | Si5-N14 is a siloxane-based lipid nanoparticle component that enhances vascular repair and exhibits anti-tumor properties. It effectively facilitates CRISPR-Cas9 editing in transgenic GFP mice and demonstrates an ability to knock out Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in Lewis lung carcinoma models, contributing to tumor suppression. Additionally, Si5-N14 has been shown to deliver Fibroblast Growth Factor-2 (FGF-2) mRNA in models of viral-induced lung injury, promoting vascular repair, increasing blood oxygen levels, and enhancing lung function. This reagent holds significant potential for research applications in oncology, pulmonary disease, and cardiovascular health. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
