Product Data Sheet
Pazopanib-d3 hydrochloride
Catalog No. A33586
Pazopanib-d3 hydrochloride is a deuterated form of Pazopanib, serving as a stable isotope labeled compound. This multi-targeted inhibitor effectively modulates several receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with respective IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM. Its unique isotopic signature allows for precise tracking and analysis in biological studies, making it suitable for pharmacokinetic research and metabolic studies in oncology and related fields.
Chemical Information
| Catalog Num | A33586 |
|---|---|
| M. Wt | 477.00 |
| Formula | C21H21D3ClN7O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2469755-67-5 |
| Synonyms | GW786034-d3 hydrochloride |
| SMILES | O=S(C1=CC(NC2=NC=CC(N(C([2H])([2H])[2H])C3=CC4=NN(C)C(C)=C4C=C3)=N2)=CC=C1C)(N)=O.Cl |
Biological Activity
| Description | Pazopanib-d3 hydrochloride is a deuterated form of Pazopanib, serving as a stable isotope labeled compound. This multi-targeted inhibitor effectively modulates several receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with respective IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM. Its unique isotopic signature allows for precise tracking and analysis in biological studies, making it suitable for pharmacokinetic research and metabolic studies in oncology and related fields. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
