Product Data Sheet
Pemigatinib-d6
Catalog No. A33589
Pemigatinib-d6 is a deuterated form of Pemigatinib, a selective inhibitor of the fibroblast growth factor receptors (FGFR). This compound exhibits remarkable potency, with IC50 values of 0.4 nM, 0.5 nM, 1.2 nM, and 30 nM against FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Pemigatinib-d6 serves as an important tool in research applications focused on cholangiocarcinoma and other malignancies associated with aberrant FGFR signaling. The stable isotope labeling facilitates comprehensive pharmacokinetic studies and metabolic profiling.
Chemical Information
| Catalog Num | A33589 |
|---|---|
| M. Wt | 493.54 |
| Formula | C24H21D6F2N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2649492-49-7 |
| Synonyms | INCB054828-d6 |
| SMILES | O=C1N(C2=C3C(NC(CN4CCOCC4)=C3)=NC=C2CN1C5=C(C(OC([2H])([2H])[2H])=CC(OC([2H])([2H])[2H])=C5F)F)CC |
Biological Activity
| Description | Pemigatinib-d6 is a deuterated form of Pemigatinib, a selective inhibitor of the fibroblast growth factor receptors (FGFR). This compound exhibits remarkable potency, with IC50 values of 0.4 nM, 0.5 nM, 1.2 nM, and 30 nM against FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Pemigatinib-d6 serves as an important tool in research applications focused on cholangiocarcinoma and other malignancies associated with aberrant FGFR signaling. The stable isotope labeling facilitates comprehensive pharmacokinetic studies and metabolic profiling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
