Product Data Sheet
Bosutinib hydrate
Catalog No. A33595
Bosutinib hydrate is an orally active Src/Abl tyrosine kinase inhibitor, demonstrating IC50 values of 1.2 nM and 1 nM for Src and Abl, respectively. This compound effectively disrupts signaling pathways involved in cell proliferation and survival, making it valuable for research in cancer biology, particularly in the study of chronic myeloid leukemia (CML) and other malignancies characterized by aberrant Src/Abl activity. Its potent inhibitory profile supports investigations into therapeutic interventions targeting these kinases.
Chemical Information
| Catalog Num | A33595 |
|---|---|
| M. Wt | 548.46 |
| Formula | C26H31Cl2N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 918639-08-4 |
| Synonyms | SKI-606 hydrate |
| SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC.O |
Biological Activity
| Description | Bosutinib hydrate is an orally active Src/Abl tyrosine kinase inhibitor, demonstrating IC50 values of 1.2 nM and 1 nM for Src and Abl, respectively. This compound effectively disrupts signaling pathways involved in cell proliferation and survival, making it valuable for research in cancer biology, particularly in the study of chronic myeloid leukemia (CML) and other malignancies characterized by aberrant Src/Abl activity. Its potent inhibitory profile supports investigations into therapeutic interventions targeting these kinases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
