Product Data Sheet
Imatinib-d3 hydrochloride
Catalog No. A33615
Imatinib-d3 hydrochloride is a deuterium-labeled derivative of Imatinib, a potent inhibitor of tyrosine kinases. It selectively targets BCR/ABL, PDGFR, and c-kit, effectively inhibiting their enzymatic activity by binding near the ATP binding site and maintaining a closed conformation. This unique stable isotope can be utilized in pharmacokinetic studies and metabolic profiling, aiding research on drug metabolism and biomarkers. Additionally, Imatinib exhibits inhibitory effects on SARS-CoV and MERS-CoV, making it relevant for investigations into viral inhibition mechanisms.
Chemical Information
| Catalog Num | A33615 |
|---|---|
| M. Wt | 496.62 |
| Formula | C29H28D3N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1134803-18-1 |
| Synonyms | STI571-d3 hydrochloride; CGP-57148B-d3 hydrochloride |
| SMILES | O=C(C1=CC=C(C=C1)CN2CCN(CC2)C([2H])([2H])[2H])NC3=CC=C(C)C(NC4=NC=CC(C5=CN=CC=C5)=N4)=C3 |
Biological Activity
| Description | Imatinib-d3 hydrochloride is a deuterium-labeled derivative of Imatinib, a potent inhibitor of tyrosine kinases. It selectively targets BCR/ABL, PDGFR, and c-kit, effectively inhibiting their enzymatic activity by binding near the ATP binding site and maintaining a closed conformation. This unique stable isotope can be utilized in pharmacokinetic studies and metabolic profiling, aiding research on drug metabolism and biomarkers. Additionally, Imatinib exhibits inhibitory effects on SARS-CoV and MERS-CoV, making it relevant for investigations into viral inhibition mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
