Product Data Sheet
FLT3/D835Y-IN-1
Catalog No. A33715
FLT3/D835Y-IN-1 is a potent and selective inhibitor targeting FLT3 and the FLT3/D835Y mutant with IC50 values of 0.26 nM and 0.18 nM, respectively. This orally active compound demonstrates significant inhibition of tumor growth and exhibits anticancer efficacy, making it a valuable tool for research into acute myeloid leukemia (AML). FLT3/D835Y-IN-1 provides a targeted approach for studying the effects of FLT3 mutations in cellular and animal models of AML.
Chemical Information
| Catalog Num | A33715 |
|---|---|
| M. Wt | 403.43 |
| Formula | C22H21N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2648799-49-7 |
| Synonyms | |
| SMILES | O=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OCC(N5CCNCC5)=O |
Biological Activity
| Description | FLT3/D835Y-IN-1 is a potent and selective inhibitor targeting FLT3 and the FLT3/D835Y mutant with IC50 values of 0.26 nM and 0.18 nM, respectively. This orally active compound demonstrates significant inhibition of tumor growth and exhibits anticancer efficacy, making it a valuable tool for research into acute myeloid leukemia (AML). FLT3/D835Y-IN-1 provides a targeted approach for studying the effects of FLT3 mutations in cellular and animal models of AML. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
