Product Data Sheet
LML134
Catalog No. A33897
LML134 is a highly selective inverse agonist of the Histamine 3 receptor (H3R), demonstrating an impressive affinity with Ki values of 0.3 nM for hH3R cAMP and 12 nM for hH3R binding. This compound exhibits rapid brain penetration, resulting in significant H3R occupancy and a swift disengagement from its target. LML134 holds promise for investigating therapeutic strategies for sleep disorders by modulating histaminergic signaling pathways.
Chemical Information
| Catalog Num | A33897 |
|---|---|
| M. Wt | 375.47 |
| Formula | C19H29N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1542135-76-1 |
| Synonyms | |
| SMILES | O=C(OC1CCN(C2=NN(C)C(C=C2)=O)CC1)N3CCN(C4CCC4)CC3 |
Biological Activity
| Description | LML134 is a highly selective inverse agonist of the Histamine 3 receptor (H3R), demonstrating an impressive affinity with Ki values of 0.3 nM for hH3R cAMP and 12 nM for hH3R binding. This compound exhibits rapid brain penetration, resulting in significant H3R occupancy and a swift disengagement from its target. LML134 holds promise for investigating therapeutic strategies for sleep disorders by modulating histaminergic signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
