Product Data Sheet
Astemizole-d3
Catalog No. A33898
Astemizole-d3 is a deuterium-labeled derivative of Astemizole, a second-generation antihistamine primarily functioning as a histamine H1-receptor antagonist, exhibiting an IC50 of 4 nM. This compound is not only effective in alleviating allergic symptoms but also possesses significant hERG K+ channel blocking activity, with an IC50 of 0.9 nM. Astemizole-d3 is valuable in pharmacokinetic studies and drug metabolism research, providing a stable isotope for tracing and quantitative analysis in biological systems.
Chemical Information
| Catalog Num | A33898 |
|---|---|
| M. Wt | 461.59 |
| Formula | C28H28D3FN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1189961-39-4 |
| Synonyms | |
| SMILES | [2H]C([2H])([2H])OC(C=C1)=CC=C1CCN(CC2)CCC2NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F |
Biological Activity
| Description | Astemizole-d3 is a deuterium-labeled derivative of Astemizole, a second-generation antihistamine primarily functioning as a histamine H1-receptor antagonist, exhibiting an IC50 of 4 nM. This compound is not only effective in alleviating allergic symptoms but also possesses significant hERG K+ channel blocking activity, with an IC50 of 0.9 nM. Astemizole-d3 is valuable in pharmacokinetic studies and drug metabolism research, providing a stable isotope for tracing and quantitative analysis in biological systems. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
