Product Data Sheet
Samelisant free base
Catalog No. A33921
Samelisant free base is a selective inverse agonist of the histamine H3 receptor (H3R) that exhibits high binding affinity (Ki values of 8.7 nM for human H3R and 9.8 nM for rat H3R). It demonstrates effective brain penetration and oral bioavailability, making it a valuable tool in the study of sleep-related disorders. Research applications include exploring the mechanisms underlying sleep regulation and potential therapeutic interventions for insomnia and other sleep disturbances.
Chemical Information
| Catalog Num | A33921 |
|---|---|
| M. Wt | 373.49 |
| Formula | C21H31N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1394808-82-2 |
| Synonyms | SUVN-G3031 free base |
| SMILES | O=C(NC1=CC=C(OC2CCN(C3CCC3)CC2)C=C1)CN4CCOCC4 |
Biological Activity
| Description | Samelisant free base is a selective inverse agonist of the histamine H3 receptor (H3R) that exhibits high binding affinity (Ki values of 8.7 nM for human H3R and 9.8 nM for rat H3R). It demonstrates effective brain penetration and oral bioavailability, making it a valuable tool in the study of sleep-related disorders. Research applications include exploring the mechanisms underlying sleep regulation and potential therapeutic interventions for insomnia and other sleep disturbances. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
