Product Data Sheet
A-331440
Catalog No. A33943
A-331440 is a selective antagonist of the histamine H3 receptor, which plays a critical role in the regulation of neurotransmitter release through inhibition at presynaptic sites. In preclinical studies with mice subjected to a high-fat diet, A-331440 demonstrated significant dose-dependent effects on body weight and fat loss. At a dosage of 5 mg/kg, it effectively reduced body weight akin to dexfenfluramine, while a 15 mg/kg dose led to substantial reductions in body fat and enhanced insulin tolerance, resembling the metabolic profile of mice on a low-fat diet. These results indicate A-331440's potential as an antiobesity agent by influencing histaminergic pathways related to appetite control and metabolic processes.
Chemical Information
| Catalog Num | A33943 |
|---|---|
| M. Wt | 349.47 |
| Formula | C22H27N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 392338-13-5 |
| Synonyms | |
| SMILES | CN(C)[C@H](CC1)CN1CCCOC2=CC=C(C3=CC=C(C=C3)C#N)C=C2 |
Biological Activity
| Description | A-331440 is a selective antagonist of the histamine H3 receptor, which plays a critical role in the regulation of neurotransmitter release through inhibition at presynaptic sites. In preclinical studies with mice subjected to a high-fat diet, A-331440 demonstrated significant dose-dependent effects on body weight and fat loss. At a dosage of 5 mg/kg, it effectively reduced body weight akin to dexfenfluramine, while a 15 mg/kg dose led to substantial reductions in body fat and enhanced insulin tolerance, resembling the metabolic profile of mice on a low-fat diet. These results indicate A-331440's potential as an antiobesity agent by influencing histaminergic pathways related to appetite control and metabolic processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
