Product Data Sheet
H3R antagonist 6
Catalog No. A33981
H3R Antagonist 6 is a potent antagonist of the Histamine receptor 3 (H3R), exhibiting an IC50 of 5.6 nM. This compound, when labeled with 18F, demonstrates high radiochemical yield and molar activity, alongside moderate brain uptake, albeit with some off-target binding to the Sigma-1 receptor. H3R Antagonist 6 serves as a valuable PET radioligand for positron emission tomography imaging, facilitating research into central nervous system (CNS) disorders.
Chemical Information
| Catalog Num | A33981 |
|---|---|
| M. Wt | 316.41 |
| Formula | C19H25FN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2183338-59-0 |
| Synonyms | |
| SMILES | O=C(N1CCN(C2CCCC2)CC1)[C@@H]3[C@@H](C4=CC=C(F)C=C4)C3 |
Biological Activity
| Description | H3R Antagonist 6 is a potent antagonist of the Histamine receptor 3 (H3R), exhibiting an IC50 of 5.6 nM. This compound, when labeled with 18F, demonstrates high radiochemical yield and molar activity, alongside moderate brain uptake, albeit with some off-target binding to the Sigma-1 receptor. H3R Antagonist 6 serves as a valuable PET radioligand for positron emission tomography imaging, facilitating research into central nervous system (CNS) disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
