Product Data Sheet
Vapitadine hydrochloride
Catalog No. A34017
Vapitadine hydrochloride is a selective antihistamine agent with a primary mechanism of blocking the human histamine H1 receptor, exhibiting a binding affinity characterized by a Ki of 19 nM. This compound demonstrates significant biological activity by reducing histamine-induced lethality, with an ED50 range of 0.056-1.2 mg/kg, and effectively antagonizes cutaneous reactions to histamine, with an ED50 of 0.51-1.4 mg/kg in rat models. Vapitadine hydrochloride is suitable for research applications focusing on allergic responses and histamine-related disorders.
Chemical Information
| Catalog Num | A34017 |
|---|---|
| M. Wt | 369.29 |
| Formula | C17H22Cl2N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 279253-83-7 |
| Synonyms | |
| SMILES | O=C(C1=CN=C2N1CCC3=CC=CC=C3C24CCNCC4)N.Cl.Cl |
Biological Activity
| Description | Vapitadine hydrochloride is a selective antihistamine agent with a primary mechanism of blocking the human histamine H1 receptor, exhibiting a binding affinity characterized by a Ki of 19 nM. This compound demonstrates significant biological activity by reducing histamine-induced lethality, with an ED50 range of 0.056-1.2 mg/kg, and effectively antagonizes cutaneous reactions to histamine, with an ED50 of 0.51-1.4 mg/kg in rat models. Vapitadine hydrochloride is suitable for research applications focusing on allergic responses and histamine-related disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
