Product Data Sheet
KSK68
Catalog No. A34025
KSK68 is a high-affinity dual antagonist of the sigma-1 and histamine H3 receptors, exhibiting binding affinities with Kis of 7.7 nM for H3, 3.6 nM for sigma-1, and 22.4 nM for sigma-2 receptors. Importantly, KSK68 shows negligible affinity for other histamine receptor subtypes. This compound is particularly valuable for research into nociceptive mechanisms and neuropathic pain, providing a tool for the investigation of pain modulation pathways.
Chemical Information
| Catalog Num | A34025 |
|---|---|
| M. Wt | 364.48 |
| Formula | C23H28N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2566715-91-9 |
| Synonyms | |
| SMILES | O=C(C1CC1)C2=CC=C(OCCCN3CCC(C4=CC=NC=C4)CC3)C=C2 |
Biological Activity
| Description | KSK68 is a high-affinity dual antagonist of the sigma-1 and histamine H3 receptors, exhibiting binding affinities with Kis of 7.7 nM for H3, 3.6 nM for sigma-1, and 22.4 nM for sigma-2 receptors. Importantly, KSK68 shows negligible affinity for other histamine receptor subtypes. This compound is particularly valuable for research into nociceptive mechanisms and neuropathic pain, providing a tool for the investigation of pain modulation pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
