Product Data Sheet
AVN-101
Catalog No. A34030
AVN-101 is a potent 5-HT7 receptor antagonist with a Ki of 153 pM, demonstrating significant brain penetration and oral bioavailability. It also interacts with 5-HT6, 5-HT2A, and 5-HT2C receptors, exhibiting Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively. Additionally, AVN-101 has a high affinity for histamine H1 and adrenergic α2A, α2B, and α2C receptors, with Ki values ranging from 0.41 to 3.6 nM. This compound is suitable for research related to general anxiety disorders, depression, schizophrenia, Alzheimer’s disease, and multiple sclerosis.
Chemical Information
| Catalog Num | A34030 |
|---|---|
| M. Wt | 304.43 |
| Formula | C21H24N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1025725-91-0 |
| Synonyms | |
| SMILES | CC1=CC2=C(N(CCC3=CC=CC=C3)C4=C2CN(C)CC4)C=C1 |
Biological Activity
| Description | AVN-101 is a potent 5-HT7 receptor antagonist with a Ki of 153 pM, demonstrating significant brain penetration and oral bioavailability. It also interacts with 5-HT6, 5-HT2A, and 5-HT2C receptors, exhibiting Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively. Additionally, AVN-101 has a high affinity for histamine H1 and adrenergic α2A, α2B, and α2C receptors, with Ki values ranging from 0.41 to 3.6 nM. This compound is suitable for research related to general anxiety disorders, depression, schizophrenia, Alzheimer’s disease, and multiple sclerosis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
