Product Data Sheet
A-349821
Catalog No. A34124
A-349821 is a histamine H3 receptor antagonist that functions as a radioligand ([3H]-A-349821) for assessing in vivo receptor occupancy. In rodent studies, [3H]-A-349821 demonstrates significant brain penetration, with a marked preference for cortical binding over the cerebellum, indicating selective interaction with H3 receptors. Its occupancy in the cortex is saturable and aligns with in vitro binding affinities. Competitive inhibition studies reveal dose-dependent reductions in receptor occupancy, correlating with blood concentrations associated with cognitive enhancement in preclinical models. This compound represents a valuable tracer for H3 receptor occupancy, facilitating the development and clinical analysis of H3 receptor antagonists.
Chemical Information
| Catalog Num | A34124 |
|---|---|
| M. Wt | 536.58 |
| Formula | C28H35F3N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 556835-30-4 |
| Synonyms | |
| SMILES | FC(F)(C(O)=O)F.C[C@H](CC[C@H]1C)N1CCCOC2=CC=C(C3=CC=C(C(N4CCOCC4)=O)C=C3)C=C2 |
Biological Activity
| Description | A-349821 is a histamine H3 receptor antagonist that functions as a radioligand ([3H]-A-349821) for assessing in vivo receptor occupancy. In rodent studies, [3H]-A-349821 demonstrates significant brain penetration, with a marked preference for cortical binding over the cerebellum, indicating selective interaction with H3 receptors. Its occupancy in the cortex is saturable and aligns with in vitro binding affinities. Competitive inhibition studies reveal dose-dependent reductions in receptor occupancy, correlating with blood concentrations associated with cognitive enhancement in preclinical models. This compound represents a valuable tracer for H3 receptor occupancy, facilitating the development and clinical analysis of H3 receptor antagonists. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
