Product Data Sheet
A-317920
Catalog No. A34192
A-317920 is a selective and potent antagonist of the histamine H3 receptor (H3R), demonstrating a pKi value of 9.2 for the rat and 7.0 for the human H3R, reflecting over 130-fold selectivity for the rat receptor. This compound has been shown to enhance cognitive function through blockade of H3R activity. A-317920 is valuable for research focused on cognition, neuropharmacology, and the role of histamine receptors in the central nervous system.
Chemical Information
| Catalog Num | A34192 |
|---|---|
| M. Wt | 453.53 |
| Formula | C25H31N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 360551-59-3 |
| Synonyms | |
| SMILES | O=C(N[C@@H](C(N1CCN(CC1)CCCOC2=CC=C(C=C2)C(C3CC3)=O)=O)C)C4=CC=CO4 |
Biological Activity
| Description | A-317920 is a selective and potent antagonist of the histamine H3 receptor (H3R), demonstrating a pKi value of 9.2 for the rat and 7.0 for the human H3R, reflecting over 130-fold selectivity for the rat receptor. This compound has been shown to enhance cognitive function through blockade of H3R activity. A-317920 is valuable for research focused on cognition, neuropharmacology, and the role of histamine receptors in the central nervous system. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
