Product Data Sheet
(R)-(+)-Mequitazine
Catalog No. A34238
(R)-(+)-Mequitazine is a histamine H1 receptor antagonist that inhibits histamine activity by competitively binding to H1 receptors in gastrointestinal, vascular, and respiratory tissues. This compound undergoes biotransformation in human liver microsomes, producing hydroxylated and S-oxidized metabolites. Additionally, (R)-(+)-Mequitazine has been shown to inhibit CYP3A-catalyzed midazolam 1'-hydroxylase activity. Its properties make it a valuable reagent for investigating various allergic diseases and related pharmacological studies.
Chemical Information
| Catalog Num | A34238 |
|---|---|
| M. Wt | 322.47 |
| Formula | C20H22N2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 147780-50-5 |
| Synonyms | |
| SMILES | C12=CC=CC=C1N(C[C@H]3CN4CCC3CC4)C5=C(C=CC=C5)S2 |
Biological Activity
| Description | (R)-(+)-Mequitazine is a histamine H1 receptor antagonist that inhibits histamine activity by competitively binding to H1 receptors in gastrointestinal, vascular, and respiratory tissues. This compound undergoes biotransformation in human liver microsomes, producing hydroxylated and S-oxidized metabolites. Additionally, (R)-(+)-Mequitazine has been shown to inhibit CYP3A-catalyzed midazolam 1'-hydroxylase activity. Its properties make it a valuable reagent for investigating various allergic diseases and related pharmacological studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
