Product Data Sheet
FAK-IN-16
Catalog No. A34290
FAK-IN-16 is a selective inhibitor of focal adhesion kinase (FAK) that exhibits an exceptionally low IC50 of 1.2 pM. This compound effectively inhibits FAK phosphorylation at both pFAK[Y397] and pFAK[Y861], resulting in decreased tumor growth and reduced vascularity and invasiveness. Additionally, FAK-IN-16 enhances the effects of Cisplatin on tumor cell proliferation and apoptosis in vitro, as well as its anti-tumor properties in murine models. This reagent is valuable for researchers focusing on cancer therapy and tumor biology.
Chemical Information
| Catalog Num | A34290 |
|---|---|
| M. Wt | 759.80 |
| Formula | C37H49F3N7O5P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1257994-15-2 |
| Synonyms | |
| SMILES | COC1=CC(CP(OCC)(OCC)=O)=CC=C1NC2=NC=C(C(F)(F)F)C(NC3=CC=C([C@H]4CC[C@H](N5CCN(C)CC5)CC4)C(CN6C)=C3C6=O)=N2 |
Biological Activity
| Description | FAK-IN-16 is a selective inhibitor of focal adhesion kinase (FAK) that exhibits an exceptionally low IC50 of 1.2 pM. This compound effectively inhibits FAK phosphorylation at both pFAK[Y397] and pFAK[Y861], resulting in decreased tumor growth and reduced vascularity and invasiveness. Additionally, FAK-IN-16 enhances the effects of Cisplatin on tumor cell proliferation and apoptosis in vitro, as well as its anti-tumor properties in murine models. This reagent is valuable for researchers focusing on cancer therapy and tumor biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
