Product Data Sheet
Dalmelitinib
Catalog No. A34310
Dalmelitinib is a selective c-Met kinase inhibitor with an IC50 of 2.9 nM, targeting the ATP-binding region of the c-Met receptor. This compound effectively induces phosphorylation of MET while partially or completely inhibiting the phosphorylation of downstream signaling proteins AKT and ERK. Dalmelitinib demonstrates potent anti-proliferative effects on cancer cells with c-Met oncogene amplification, making it a valuable reagent for research applications in cancers such as human non-small cell lung cancer (NSCLC).
Chemical Information
| Catalog Num | A34310 |
|---|---|
| M. Wt | 461.47 |
| Formula | C22H16FN7O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1637658-98-0 |
| Synonyms | |
| SMILES | O=C1N(C)C2=CN=C3C=CC(SC4=NN=C5C(F)=CC(C6=CN(C)N=C6)=CN45)=CC3=C2OC1 |
Biological Activity
| Description | Dalmelitinib is a selective c-Met kinase inhibitor with an IC50 of 2.9 nM, targeting the ATP-binding region of the c-Met receptor. This compound effectively induces phosphorylation of MET while partially or completely inhibiting the phosphorylation of downstream signaling proteins AKT and ERK. Dalmelitinib demonstrates potent anti-proliferative effects on cancer cells with c-Met oncogene amplification, making it a valuable reagent for research applications in cancers such as human non-small cell lung cancer (NSCLC). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
