Product Data Sheet
KIN-8741
Catalog No. A34339
KIN-8741 is a highly selective Type IIb c-Met inhibitor that targets the c-Met kinase, effectively addressing various mutations associated with this oncogenic pathway. Demonstrating significant antitumor activity, KIN-8741 is particularly effective in models of non-small cell lung cancer characterized by MET gene amplification and exon 14 deletions. This reagent is suitable for research applications focusing on c-Met-driven cancers, especially in advanced tumors with MET exon 14 jump mutations and acquired drug resistance.
Chemical Information
| Catalog Num | A34339 |
|---|---|
| M. Wt | 511.47 |
| Formula | C26H23F2N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2941104-53-4 |
| Synonyms | |
| SMILES | FC1=CC(NC(C2=C(C=CN=C2)OC)=O)=CC(F)=C1OC3=CC=NC4=CC(OC)=C(C=C43)O[C@H](CO)C |
Biological Activity
| Description | KIN-8741 is a highly selective Type IIb c-Met inhibitor that targets the c-Met kinase, effectively addressing various mutations associated with this oncogenic pathway. Demonstrating significant antitumor activity, KIN-8741 is particularly effective in models of non-small cell lung cancer characterized by MET gene amplification and exon 14 deletions. This reagent is suitable for research applications focusing on c-Met-driven cancers, especially in advanced tumors with MET exon 14 jump mutations and acquired drug resistance. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
