Product Data Sheet
KRC-00715
Catalog No. A34371
KRC-00715 is a potent oral inhibitor of c-Met with an IC50 of 9.0 nM, exhibiting high selectivity for gastric cancer cells. This compound effectively induces G1/S phase arrest in c-Met-overexpressing cell lines, resulting in diminished downstream signaling through Akt and Erk pathways as well as reduced c-Met activity. In the gastric cancer cell line Hs746, KRC-00715 demonstrates an IC50 of 39 nM and shows significant efficacy in reducing tumor size in Hs746T xenograft mouse models, highlighting its potential application in cancer research and therapeutics.
Chemical Information
| Catalog Num | A34371 |
|---|---|
| M. Wt | 542.51 |
| Formula | C25H25F3N8O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2079853-72-6 |
| Synonyms | |
| SMILES | FC(F)(F)C1=C(OCCN2CCOCC2)C=CC(C3=NC(N(CC4OC(C=CC=N5)=C5NC4)N=N6)=C6N=C3)=C1 |
Biological Activity
| Description | KRC-00715 is a potent oral inhibitor of c-Met with an IC50 of 9.0 nM, exhibiting high selectivity for gastric cancer cells. This compound effectively induces G1/S phase arrest in c-Met-overexpressing cell lines, resulting in diminished downstream signaling through Akt and Erk pathways as well as reduced c-Met activity. In the gastric cancer cell line Hs746, KRC-00715 demonstrates an IC50 of 39 nM and shows significant efficacy in reducing tumor size in Hs746T xenograft mouse models, highlighting its potential application in cancer research and therapeutics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
