Product Data Sheet
Atuzabrutinib
Catalog No. A34404
Atuzabrutinib is a selective reversible inhibitor of Bruton's tyrosine kinase (Btk), which plays a crucial role in B-cell receptor signaling. This compound demonstrates significant inhibition of neutrophil recruitment through the modulation of macrophage antigen-1 signaling pathways. Atuzabrutinib is primarily utilized in research focused on B-cell mediated autoimmunity, chronic inflammatory diseases, and various malignancies. Its targeted action on Btk makes it valuable in studying therapeutics aimed at B-cell related disorders.
Chemical Information
| Catalog Num | A34404 |
|---|---|
| M. Wt | 539.60 |
| Formula | C30H30FN7O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1581714-49-9 |
| Synonyms | SAR 444727; PRN473 |
| SMILES | NC1=C2C(N([C@H]3CN(CCC3)C(/C(C#N)=C/C(C)(C)C)=O)N=C2C4=C(C=C(C=C4)OC5=CC=CC=C5)F)=NC=N1 |
Biological Activity
| Description | Atuzabrutinib is a selective reversible inhibitor of Bruton's tyrosine kinase (Btk), which plays a crucial role in B-cell receptor signaling. This compound demonstrates significant inhibition of neutrophil recruitment through the modulation of macrophage antigen-1 signaling pathways. Atuzabrutinib is primarily utilized in research focused on B-cell mediated autoimmunity, chronic inflammatory diseases, and various malignancies. Its targeted action on Btk makes it valuable in studying therapeutics aimed at B-cell related disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
