Product Data Sheet
Humantenine
Catalog No. A34559
Humantenine is a highly toxic indole alkaloid derived from Gelsemium elegans. It specifically targets RNA m6A modification regulatory proteins, including ALKBH5 and METTL, where it binds stably through hydrogen bonding and hydrophobic interactions. This binding disrupts m6A methylation levels of target genes, leading to impaired expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, ultimately resulting in intestinal barrier dysfunction and substantial cytotoxicity. In animal studies, Humantenine exhibits an intraperitoneal LD50 of less than 1 mg/kg in mice. Its metabolism varies across species, with notable demethylation, dehydrogenation, and oxidation observed in liver microsomes of humans, pigs, goats, and rats.
Chemical Information
| Catalog Num | A34559 |
|---|---|
| M. Wt | 354.44 |
| Formula | C21H26N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 82375-29-9 |
| Synonyms | |
| SMILES | O=C1N(C2=C(C=CC=C2)[C@@]13[C@@]4([H])C[C@]5([H])[C@@](CO4)([H])[C@](N(C/C5=C\C)C)([H])C3)OC |
Biological Activity
| Description | Humantenine is a highly toxic indole alkaloid derived from Gelsemium elegans. It specifically targets RNA m6A modification regulatory proteins, including ALKBH5 and METTL, where it binds stably through hydrogen bonding and hydrophobic interactions. This binding disrupts m6A methylation levels of target genes, leading to impaired expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, ultimately resulting in intestinal barrier dysfunction and substantial cytotoxicity. In animal studies, Humantenine exhibits an intraperitoneal LD50 of less than 1 mg/kg in mice. Its metabolism varies across species, with notable demethylation, dehydrogenation, and oxidation observed in liver microsomes of humans, pigs, goats, and rats. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
