Product Data Sheet
Avapritinib-d3
Catalog No. A34599
Avapritinib-d3 is a deuterium-labeled derivative of Avapritinib, a potent and selective inhibitor of mutant kinase targets KIT and PDGFRA. It demonstrates remarkable biological activity with IC50 values of 0.27 nM and 0.24 nM for KIT D816V and PDGFRA D842V mutations, respectively. Avapritinib-d3 binds to the active conformation of these kinases, contributing to its antitumor effects, and it also inhibits the transport functions of ABCB1 and ABCG2. This stable isotope variant is useful for pharmacokinetic studies and tracer applications in chemical research.
Chemical Information
| Catalog Num | A34599 |
|---|---|
| M. Wt | 501.58 |
| Formula | C26H24D3FN10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2408934-57-4 |
| Synonyms | BLU-285-d3 |
| SMILES | C[C@](N)(C1=CC=C(C=C1)F)C2=CN=C(N=C2)N(CC3)CCN3C4=NC=NN5C4=CC(C(C=N6)=CN6C([2H])([2H])[2H])=C5 |
Biological Activity
| Description | Avapritinib-d3 is a deuterium-labeled derivative of Avapritinib, a potent and selective inhibitor of mutant kinase targets KIT and PDGFRA. It demonstrates remarkable biological activity with IC50 values of 0.27 nM and 0.24 nM for KIT D816V and PDGFRA D842V mutations, respectively. Avapritinib-d3 binds to the active conformation of these kinases, contributing to its antitumor effects, and it also inhibits the transport functions of ABCB1 and ABCG2. This stable isotope variant is useful for pharmacokinetic studies and tracer applications in chemical research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
