Product Data Sheet
GW2580-d6
Catalog No. A34613
GW2580-d6 is a deuterium-labeled variant of GW2580, a selective and orally bioavailable inhibitor of c-Fms kinase. It effectively inhibits human c-Fms kinase in vitro at a concentration of 0.06 μM by acting as a competitive inhibitor of ATP binding, thereby disrupting colony-stimulating factor-1 (CSF-1) signaling pathways. This reagent is valuable for studying signaling processes mediated by c-Fms in various biological contexts and provides insights into macrophage biology and inflammatory responses.
Chemical Information
| Catalog Num | A34613 |
|---|---|
| M. Wt | 372.45 |
| Formula | C20H16D6N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2733770-48-2 |
| Synonyms | |
| SMILES | NC1=NC(N)=C(CC2=CC(OC([2H])([2H])[2H])=C(OCC3=CC=C(OC([2H])([2H])[2H])C=C3)C=C2)C=N1 |
Biological Activity
| Description | GW2580-d6 is a deuterium-labeled variant of GW2580, a selective and orally bioavailable inhibitor of c-Fms kinase. It effectively inhibits human c-Fms kinase in vitro at a concentration of 0.06 μM by acting as a competitive inhibitor of ATP binding, thereby disrupting colony-stimulating factor-1 (CSF-1) signaling pathways. This reagent is valuable for studying signaling processes mediated by c-Fms in various biological contexts and provides insights into macrophage biology and inflammatory responses. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
