Product Data Sheet
Vociprotafib
Catalog No. A34646
Vociprotafib is a potent and selective inhibitor of the phosphatase SHP2, primarily targeting the RAS-RAF-MEK-ERK signaling pathway. This compound exhibits significant antitumor activity, demonstrated by its ability to accelerate and enhance tumor regressions in mouse models of Osimertinib-sensitive EGFR-mutant tumors. Vociprotafib serves as a valuable tool for research in cancer biology, particularly in studies aimed at elucidating the role of SHP2 in oncogenesis and therapeutic resistance.
Chemical Information
| Catalog Num | A34646 |
|---|---|
| M. Wt | 450.99 |
| Formula | C20H27ClN6O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2172652-48-9 |
| Synonyms | RMC-4630; SHP2-IN-7 |
| SMILES | N[C@H]1C2(CO[C@H]1C)CCN(C3=NC(C)=C(SC4=CC=NC(N)=C4Cl)N=C3CO)CC2 |
Biological Activity
| Description | Vociprotafib is a potent and selective inhibitor of the phosphatase SHP2, primarily targeting the RAS-RAF-MEK-ERK signaling pathway. This compound exhibits significant antitumor activity, demonstrated by its ability to accelerate and enhance tumor regressions in mouse models of Osimertinib-sensitive EGFR-mutant tumors. Vociprotafib serves as a valuable tool for research in cancer biology, particularly in studies aimed at elucidating the role of SHP2 in oncogenesis and therapeutic resistance. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
