Product Data Sheet
Casdatifan
Catalog No. A34759
Casdatifan is an orally bioavailable allosteric inhibitor targeting hypoxia-inducible factor 2α (HIF-2α). It functions by preventing the heterodimerization of HIF-2α with ARNT, thereby inhibiting pro-tumor gene transcription. Casdatifan has demonstrated significant tumor growth suppression in clear cell renal cell carcinoma (ccRCC) models, both as a single agent and in combination therapies. This reagent is valuable for research related to ccRCC and HIF-2α signaling pathways.
Chemical Information
| Catalog Num | A34759 |
|---|---|
| M. Wt | 439.42 |
| Formula | C21H17F4NO3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2709069-30-5 |
| Synonyms | AB521 |
| SMILES | CS(C(C1=C2C[C@@H](F)[C@H]1O)=CC=C2[C@](C[C@H](F)[C@@H]3F)([H])C4=C3C=C(F)C=C4C#N)(=O)=O |
Biological Activity
| Description | Casdatifan is an orally bioavailable allosteric inhibitor targeting hypoxia-inducible factor 2α (HIF-2α). It functions by preventing the heterodimerization of HIF-2α with ARNT, thereby inhibiting pro-tumor gene transcription. Casdatifan has demonstrated significant tumor growth suppression in clear cell renal cell carcinoma (ccRCC) models, both as a single agent and in combination therapies. This reagent is valuable for research related to ccRCC and HIF-2α signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
