Product Data Sheet
Guluronic acid
Catalog No. A34772
Guluronic acid is an oxidative stress modulator and anti-inflammatory agent. It functions by down-regulating pro-inflammatory genes such as TLR4, NF-κB, and iNOS, while inhibiting COX-2, MMPs, and VEGF activity. This compound promotes the up-regulation of immunoregulatory genes including SHIP1 and SOCS1, thereby mitigating cancer-related inflammation, tumor angiogenesis, cell adhesion, and metastasis, while decreasing immunosuppressive cell accumulation. Guluronic acid has demonstrated potential in extending survival times in tumor-bearing hosts within a non-cytotoxic concentration range and has applications in research related to multiple sclerosis, ankylosing spondylitis, breast cancer, and other inflammatory diseases.
Chemical Information
| Catalog Num | A34772 |
|---|---|
| M. Wt | 194.14 |
| Formula | C6H10O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 15769-56-9 |
| Synonyms | G2013 |
| SMILES | O=C[C@@H]([C@@H]([C@H]([C@@H](C(O)=O)O)O)O)O |
Biological Activity
| Description | Guluronic acid is an oxidative stress modulator and anti-inflammatory agent. It functions by down-regulating pro-inflammatory genes such as TLR4, NF-κB, and iNOS, while inhibiting COX-2, MMPs, and VEGF activity. This compound promotes the up-regulation of immunoregulatory genes including SHIP1 and SOCS1, thereby mitigating cancer-related inflammation, tumor angiogenesis, cell adhesion, and metastasis, while decreasing immunosuppressive cell accumulation. Guluronic acid has demonstrated potential in extending survival times in tumor-bearing hosts within a non-cytotoxic concentration range and has applications in research related to multiple sclerosis, ankylosing spondylitis, breast cancer, and other inflammatory diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
