Product Data Sheet
Tivozanib-d6
Catalog No. A34858
Tivozanib-d6 is a deuterium-labeled form of Tivozanib, a selective inhibitor of vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), demonstrating IC50 values of 30 nM, 6.5 nM, and 15 nM, respectively. This reagent is employed in chemical research to track the metabolism and pharmacokinetics of Tivozanib in various biological systems. Its application is particularly relevant in studies focused on tumor growth inhibition and angiogenesis modulation, enhancing understanding of targeted cancer therapies.
Chemical Information
| Catalog Num | A34858 |
|---|---|
| M. Wt | 460.90 |
| Formula | C22H13D6ClN4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1714998-87-4 |
| Synonyms | AV-951-d6; KRN951-d6 |
| SMILES | O=C(NC1=NOC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C34)C=C2Cl |
Biological Activity
| Description | Tivozanib-d6 is a deuterium-labeled form of Tivozanib, a selective inhibitor of vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), demonstrating IC50 values of 30 nM, 6.5 nM, and 15 nM, respectively. This reagent is employed in chemical research to track the metabolism and pharmacokinetics of Tivozanib in various biological systems. Its application is particularly relevant in studies focused on tumor growth inhibition and angiogenesis modulation, enhancing understanding of targeted cancer therapies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
