Product Data Sheet
Regorafénib N-oxyde-d3(M2)
Catalog No. A34883
Regorafénib N-oxyde-d3(M2) is a deuterium-labeled analog of Regorafénib N-oxyde M2, an active metabolite of the multi-targeted inhibitor Regorafenib. This compound targets key receptors including VEGFR1/2/3, PDGFRβ, Kit, RET, and Raf-1, exhibiting IC50 values of 13, 4.2, 46, 22, 7, 1.5, and 2.5 nM, respectively. Regorafénib N-oxyde-d3(M2) is primarily utilized in stable isotope labeling studies to trace metabolic pathways and explore pharmacokinetics in research applications.
Chemical Information
| Catalog Num | A34883 |
|---|---|
| M. Wt | 501.83 |
| Formula | C21H12D3ClF4N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1333489-03-4 |
| Synonyms | |
| SMILES | [2H]C([2H])([2H])NC(C1=CC(OC2=CC(F)=C(C=C2)NC(NC3=CC(C(F)(F)F)=C(C=C3)Cl)=O)=CC=[N+]1[O-])=O |
Biological Activity
| Description | Regorafénib N-oxyde-d3(M2) is a deuterium-labeled analog of Regorafénib N-oxyde M2, an active metabolite of the multi-targeted inhibitor Regorafenib. This compound targets key receptors including VEGFR1/2/3, PDGFRβ, Kit, RET, and Raf-1, exhibiting IC50 values of 13, 4.2, 46, 22, 7, 1.5, and 2.5 nM, respectively. Regorafénib N-oxyde-d3(M2) is primarily utilized in stable isotope labeling studies to trace metabolic pathways and explore pharmacokinetics in research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
