Product Data Sheet
TOP1210
Catalog No. A34940
TOP1210 is a selective tyrosine kinase inhibitor that targets Src, P38α, and Syk kinases. It demonstrates significant anti-inflammatory activity by effectively reducing the release of proinflammatory cytokines from various immune and inflammatory cell types, including peripheral blood monocytes and primary macrophages. TOP1210 shows promise in research applications related to inflammatory conditions, particularly ulcerative colitis, by offering a broader therapeutic potential through its multi-kinase inhibition profile, which may enhance the modulation of autoimmune responses.
Chemical Information
| Catalog Num | A34940 |
|---|---|
| M. Wt | 796.91 |
| Formula | C45H48N8O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1628439-59-7 |
| Synonyms | |
| SMILES | O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=CC=C(C4=C3C=CC=C4)OC5=NC(NC6=CC(C#C)=CC(C(NCCOCCOCCOC)=O)=C6)=NC=C5 |
Biological Activity
| Description | TOP1210 is a selective tyrosine kinase inhibitor that targets Src, P38α, and Syk kinases. It demonstrates significant anti-inflammatory activity by effectively reducing the release of proinflammatory cytokines from various immune and inflammatory cell types, including peripheral blood monocytes and primary macrophages. TOP1210 shows promise in research applications related to inflammatory conditions, particularly ulcerative colitis, by offering a broader therapeutic potential through its multi-kinase inhibition profile, which may enhance the modulation of autoimmune responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
