Product Data Sheet
SB 220025 (tri(hydrochloride))
Catalog No. A34955
SB 220025 (tri(hydrochloride)) is a reversible, orally active, ATP-competitive inhibitor of human p38 MAPK, with an IC50 of 60 nM. This compound also exhibits inhibition of p56Lck and PKC with IC50 values of 3.5 μM and 2.89 μM, respectively. SB 220025 trihydrochloride effectively reduces IL-8 gene expression in response to globular adiponectin and diminishes inflammatory cytokine production, making it a valuable tool for studying inflammation and angiogenesis. Additionally, it has shown efficacy in preventing the progression of arthritis in chronic inflammatory disease models.
Chemical Information
| Catalog Num | A34955 |
|---|---|
| M. Wt | 447.76 |
| Formula | C18H22Cl3FN6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 197446-75-6 |
| Synonyms | |
| SMILES | NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCNCC4)=N1.Cl.Cl.Cl |
Biological Activity
| Description | SB 220025 (tri(hydrochloride)) is a reversible, orally active, ATP-competitive inhibitor of human p38 MAPK, with an IC50 of 60 nM. This compound also exhibits inhibition of p56Lck and PKC with IC50 values of 3.5 μM and 2.89 μM, respectively. SB 220025 trihydrochloride effectively reduces IL-8 gene expression in response to globular adiponectin and diminishes inflammatory cytokine production, making it a valuable tool for studying inflammation and angiogenesis. Additionally, it has shown efficacy in preventing the progression of arthritis in chronic inflammatory disease models. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
