Product Data Sheet
ALE-0540
Catalog No. A34983
ALE-0540 is a nonpeptidic small molecule that acts as an antagonist of the nerve growth factor receptor. It effectively inhibits the binding of nerve growth factor (NGF) to the receptor tyrosine kinase A (TrkA) and the p75 neurotrophin receptor, with IC50 values of 5.88 μM and 3.72 μM, respectively. This compound is valuable for investigating the underlying mechanisms of pain and developing new therapeutic agents targeting pain pathways.
Chemical Information
| Catalog Num | A34983 |
|---|---|
| M. Wt | 301.25 |
| Formula | C14H11N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 234779-34-1 |
| Synonyms | |
| SMILES | O=C1N(NCCO)C(C2=CC([N+]([O-])=O)=CC3=CC=CC1=C23)=O |
Biological Activity
| Description | ALE-0540 is a nonpeptidic small molecule that acts as an antagonist of the nerve growth factor receptor. It effectively inhibits the binding of nerve growth factor (NGF) to the receptor tyrosine kinase A (TrkA) and the p75 neurotrophin receptor, with IC50 values of 5.88 μM and 3.72 μM, respectively. This compound is valuable for investigating the underlying mechanisms of pain and developing new therapeutic agents targeting pain pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
