Product Data Sheet
Amitriptyline-d3 hydrochloride
Catalog No. A34988
Amitriptyline-d3 hydrochloride is a deuterium-labeled derivative of amitriptyline, primarily targeting the serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET). It exhibits Ki values of 3.45 nM and 13.3 nM for human SERT and NET, respectively, and demonstrates weak binding to the dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Additionally, amitriptyline-d3 hydrochloride acts as an agonist for TrkA and TrkB receptors, exhibiting neurotrophic activity and contributing to its antidepressant effects. This stable isotope is valuable for metabolic studies and drug mechanism research.
Chemical Information
| Catalog Num | A34988 |
|---|---|
| M. Wt | 316.88 |
| Formula | C20H21D3ClN |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 342611-00-1 |
| Synonyms | |
| SMILES | [2H]C(N(C)CC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13)([2H])[2H].[H]Cl |
Biological Activity
| Description | Amitriptyline-d3 hydrochloride is a deuterium-labeled derivative of amitriptyline, primarily targeting the serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET). It exhibits Ki values of 3.45 nM and 13.3 nM for human SERT and NET, respectively, and demonstrates weak binding to the dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Additionally, amitriptyline-d3 hydrochloride acts as an agonist for TrkA and TrkB receptors, exhibiting neurotrophic activity and contributing to its antidepressant effects. This stable isotope is valuable for metabolic studies and drug mechanism research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
