Product Data Sheet
LPM4870108
Catalog No. A34992
LPM4870108 is a potent pan-Trk inhibitor, targeting wild-type and mutant variants with IC50 values of 0.2 nM for TrkC, 2.4 nM for TrkA, 3.5 nM for TrkAG595R, and 2.3 nM for TrkAG667C. It demonstrates selectivity for Trk over ALK, with an IC50 of 182 nM. LPM4870108 exhibits significant anti-tumor activity, making it a valuable tool for studying Trk-related oncogenic signaling pathways and developing targeted cancer therapies.
Chemical Information
| Catalog Num | A34992 |
|---|---|
| M. Wt | 410.40 |
| Formula | C20H19FN6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2803679-07-2 |
| Synonyms | |
| SMILES | O=C1C2=C3N(C=CC(N4[C@@H](C5=CC(F)=CN=C5OCC6(N1)CC6)COCC4)=N3)N=C2 |
Biological Activity
| Description | LPM4870108 is a potent pan-Trk inhibitor, targeting wild-type and mutant variants with IC50 values of 0.2 nM for TrkC, 2.4 nM for TrkA, 3.5 nM for TrkAG595R, and 2.3 nM for TrkAG667C. It demonstrates selectivity for Trk over ALK, with an IC50 of 182 nM. LPM4870108 exhibits significant anti-tumor activity, making it a valuable tool for studying Trk-related oncogenic signaling pathways and developing targeted cancer therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
