Product Data Sheet
Trk-IN-7
Catalog No. A34995
Trk-IN-7 is a potent TRK inhibitor targeting TRKA, TRKB, and TRKC, with IC50 values ranging from 0.25 to 10 nM. Additionally, Trk-IN-7 demonstrates significant inhibitory activity against EML4-ALK and various ALK mutations, including G1202R, C1156Y, R1275Q, F1174L, L1197M, and G1269A, with IC50 values ranging from 5 to 50 nM. This compound is valuable for research in neurotrophic signaling and cancer biology, particularly involving TRK and ALK pathways.
Chemical Information
| Catalog Num | A34995 |
|---|---|
| M. Wt | 368.36 |
| Formula | C18H17FN6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2383011-61-6 |
| Synonyms | |
| SMILES | FC1=CN=C(O[C@H]2C[C@H](C2)NC3=O)C([C@H](NC4=NC5=C3C=NN5C=C4)C)=C1 |
Biological Activity
| Description | Trk-IN-7 is a potent TRK inhibitor targeting TRKA, TRKB, and TRKC, with IC50 values ranging from 0.25 to 10 nM. Additionally, Trk-IN-7 demonstrates significant inhibitory activity against EML4-ALK and various ALK mutations, including G1202R, C1156Y, R1275Q, F1174L, L1197M, and G1269A, with IC50 values ranging from 5 to 50 nM. This compound is valuable for research in neurotrophic signaling and cancer biology, particularly involving TRK and ALK pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
