Product Data Sheet
Trk-IN-8
Catalog No. A35000
Trk-IN-8 is a potent TRK inhibitor that exhibits IC50 values of 0.42 nM for TRKAa, 0.89 nM for TRKA(G595R), and 1.5 nM for TRKC(G623R). This compound is effective in selectively targeting Tropomyosin receptor kinase (TRK) signaling pathways, making it a valuable tool for research in cancer biology and therapeutic development. Its high selectivity and potency facilitate studies of TRK-related oncogenic processes and potential treatment strategies for TRK fusion-positive tumors.
Chemical Information
| Catalog Num | A35000 |
|---|---|
| M. Wt | 386.36 |
| Formula | C18H16F2N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2762200-57-5 |
| Synonyms | |
| SMILES | O=C1N[C@H](C2)C[C@H]2OC3=NC=C(F)C=C3[C@@H](C)/N=C(N4)\C(F)=CN5C4=C1C=N5 |
Biological Activity
| Description | Trk-IN-8 is a potent TRK inhibitor that exhibits IC50 values of 0.42 nM for TRKAa, 0.89 nM for TRKA(G595R), and 1.5 nM for TRKC(G623R). This compound is effective in selectively targeting Tropomyosin receptor kinase (TRK) signaling pathways, making it a valuable tool for research in cancer biology and therapeutic development. Its high selectivity and potency facilitate studies of TRK-related oncogenic processes and potential treatment strategies for TRK fusion-positive tumors. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
